Nonlinear Statistical Data Assimilation for HVCRA Neurons in the Avian Song System

With the goal of building a model of the HVC nucleus in the avian song system, we discuss in detail a model of HVCRA projection neurons comprised of a somatic compartment with fast Na and K currents and a dendritic compartment with slower Ca dynamics. We show this model qualitatively exhibits many observed electrophysiological behaviors. We then show in numerical procedures how one can design and analyze feasible laboratory experiments that allow the estimation of all of the many parameters and unmeasured dynamical variables, given observations of the somatic voltage Vs(t) alone. A key to this procedure is to initially estimate the slow dynamics associated with Ca, blocking the fast Na and K variations, and then with the Ca parameters fixed, estimate the fast Na and N. Kadakia Department of Physics, University of California, 9500 Gilman Drive, La Jolla, CA 92903-0402 E-mail: [email protected] E. Armstrong BioCircuits Institute, University of California, 9500 Gilman Drive, La Jolla, CA 92903-0328 D. Breen · U. Morone Department of Physics, University of California, 9500 Gilman Drive, La Jolla, CA 92903-0402 A. Daou · D. Margoliash Department of Organismal Biology and Anatomy, University of Chicago, 1027 E. 57th Street, Chicago, IL 63607 H. D. I. Abarbanel Marine Physical Laboratory (Scripps Institution of Oceanography), Department of Physics, University of California, 9500 Gilman Drive, La Jolla, CA 92903 K dynamics. This separation of time scales provides a numerically robust method for completing the full neuron model, and the efficacy of the method is tested by prediction when observations are complete. The simulation provides a framework for the slice preparation experiments and illustrates the use of data assimilation methods for the design of those experiments.